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School of Health Sciences Personnel - Jason Cannon

Jason Cannon, Ph.D.
Assistant Professor of Health Sciences and Toxicology
Phone: 765-494-0794
Fax: 765-496-1377

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B.S., Physiology, Michigan State University
Ph.D., Toxicology, University of Michigan
Postdoctoral Fellow, Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh

Research: Neurodegeneration; neurotoxicology; gene-environment interactions


The majority of human diseases are thought to arise from interactions between environmental factors, genetic susceptibility, and aging.  The interplay between these factors is particularly important in neurodegenerative diseases, including Parkinson’s disease.  My laboratory primarily studies the contribution environmental exposures have in neurodegeneration and the importance of gene-environment interactions. We are exploring the role these interactions may play in disease pathogenesis. The information we have learned about these important interactions may also be used to design and test new potentially therapeutic approaches.  Specific projects include:  1) Creation of new gene-environment interaction models of neurodegeneration; 2) Characterization of newly created transgenic rat models of Parkinson’s disease; 3) Heterocyclic amine exposure and neurodegeneration; and 4) Acute pesticide exposure during development and late-life neurological dysfunction.  The major techniques utilized in my lab are:  neurobehavioral analysis, stereotaxic infusion, gene therapy/viral vector-mediated gene transfer, neurochemistry (HPLC w/electrochemical detection) and histology/microscopy.

Honors and Credentials


Tower Guard: Sophomore Honor Service Society, Michigan State University

Institutional Predoctoral Training Fellowship (3 competitive renewals), NIEHS Environmental Toxicology Research Training Grant, The University of Michigan

Rackham Travel Awards (4 times), Society of Toxicology’s  annual meeting, Rackham Graduate School, University of Michigan

Student Scholarship, 13th International Symposium on Brain Edema and Conference on Intracerebral Hemorrhage

Institutional Postdoctoral Training Fellowship, NIMH Training Grant the Neurobiology of Psychiatric Disorders, University of Pittsburgh

Postdoctoral Fellowship, American Parkinson’s Disease Association, Inc.

Best Overall Poster, 2010 Annual Spring Meeting, Allegheny-Erie Society of Toxicology

NIH (NIEHS) Individual Career Development Award (K99)

AstraZeneca Travel Award, Gordon Research Conference, Cellular & Molecular Mechanisms of Toxicity Understanding Innovative Mechanistic Toxicology in the Post-Genomic Era

Abstract chosen for oral presentation.  Gordon Research Conference, Cellular & Molecular Mechanisms of Toxicity Understanding Innovative Mechanistic Toxicology in the Post-Genomic Era

1st place in poster competition.  Gordon Research Conference, Cellular & Molecular Mechanisms of Toxicity Understanding Innovative Mechanistic Toxicology in the Post-Genomic Era  



K99/R00 (NIEHS/NIH; PI: Cannon);  “New Approaches to Gene-environment Interaction Modeling in Parkinson's Disease” 2011-2015

Representative Publications

Milanese, C., Sager, J. J., Bai, Q., Farrell, T. C., Cannon, J. R., Greenamyre, J. T. and Burton, E. A. (2012). Hypokinesia and reduced dopamine levels in zebrafish lacking beta- and gamma1-synucleins. The Journal of biological chemistry 287(5), 2971-83, 10.1074/jbc.M111.308312.


Cannon, J. R. and Greenamyre, J. T. (2011). The role of environmental exposures in neurodegeneration and neurodegenerative diseases. Toxicol Sci 124(2), 225-50, 10.1093/toxsci/kfr239.


Cannon, J. R., Sew, T., Montero, L., Burton, E. A. and Greenamyre, J. T. (2011). Pseudotype-dependent lentiviral transduction of astrocytes or neurons in the rat substantia nigra. Exp Neurol 228(1), 41-52, 10.1016/j.expneurol.2010.10.016.


Tapias, V., Cannon, J. R. and Greenamyre, J. T. (2010). Melatonin treatment potentiates neurodegeneration in a rat rotenone Parkinson's disease model. J Neurosci Res 88(2), 420-7, 10.1002/jnr.22201.


Cannon, J. R. and Greenamyre, J. T. (2010). Neurotoxic in vivo models of Parkinson's disease recent advances. Prog Brain Res 184, 17-33, 10.1016/S0079-6123(10)84002-6.


Cannon, J. R. and Greenamyre, J. T. (2009). NeuN is not a reliable marker of dopamine neurons in rat substantia nigra. Neurosci Lett 464(1), 14-7, 10.1016/j.neulet.2009.08.023.


Drolet, R. E., Cannon, J. R., Montero, L. and Greenamyre, J. T. (2009). Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology. Neurobiology of disease 36(1), 96-102, 10.1016/j.nbd.2009.06.017.


Cannon, J. R., Tapias, V., Na, H. M., Honick, A. S., Drolet, R. E. and Greenamyre, J. T. (2009). A highly reproducible rotenone model of Parkinson's disease. Neurobiology of disease 34(2), 279-90.


Cannon, J. R., Hua, Y., Richardson, R. J., Xi, G., Keep, R. F. and Schallert, T. (2007). The effect of thrombin on a 6-hydroxydopamine model of Parkinson's disease depends on timing. Behav Brain Res 183(2), 161-8, 10.1016/j.bbr.2007.06.004.


Cannon, J. R., Xi, G. and Keep, R. F. (2007). Recent research on changes in genomic regulation and protein expression in intracerebral haemorrhage. Int J Stroke 2(4), 265-9, 10.1111/j.1747-4949.2007.00160.x.


Cannon, J. R., Keep, R. F., Schallert, T., Hua, Y., Richardson, R. J. and Xi, G. (2006). Protease-activated receptor-1 mediates protection elicited by thrombin preconditioning in a rat 6-hydroxydopamine model of Parkinson's disease. Brain Res 1116(1), 177-86.


Cannon, J. R., Nakamura, T., Keep, R. F., Richardson, R. J., Hua, Y. and Xi, G. (2006). Dopamine changes in a rat model of intracerebral hemorrhage. Acta Neurochir Suppl 96, 222-6.


Cannon, J. R., Keep, R. F., Hua, Y., Richardson, R. J., Schallert, T. and Xi, G. (2005). Thrombin preconditioning provides protection in a 6-hydroxydopamine Parkinson's disease model. Neurosci Lett 373(3), 189-94.

This record was last updated on Jun 6, 2013 at 11:42 AM
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