Huiling (Linda) Nie, MSc. PhD., Assistant Professor of Radiological Health Sciences E-mail: hnie@purdue.edu Full directory listing

Education

Research: Medical Physics, Health Physics, Radiation Sciences, Environmental Health

Current research:

· Development of new biomarkers for metal exposure assessment

· Bone microdosimetry for alpha and beta particles

· Radiation shielding and dose calculation software development

· Lead exposure and helath outcomes for children and adults

· Biology Effect of Low-dose Radiation

Interests

MAJOR RESEARCH INTERESTS:

· The application of nuclear physics in environmental health. Instrumentation and methods development for the in vivo measurement of lead, cadmium, arsenic, mercury, and other metals. Systems and methodology for tracing environmental sources of metals and other pollutants.

· The application of nuclear physics in medicine. Study of radiation transport and dose distributions in biologic tissue and material. Basic research in radiotherapy and nuclear medicine.

· Radiation protection. Radiation dosimetry and microdosimetry. Development of compartmental and bio-kinetic models to assess radiation dose to radionuclide therapy patients, radiation workers, and the general population.

· Radiobiology and toxicology. Investigation of low-dose radiation effects and low-dose metal toxicity at the cellular and DNA level. Effect of radiation and toxic chemical on various end points such as cell survival, DNA damage, and gene expressions.

· General nuclear physics applications in other fields.

Teaching

TBA

Presentations

International conferences (oral presentations)

2008 Accuracy and Precision of an Advanced in vivo K-x Ray Fluorescence (KXRF) Bone Lead Measurement System. 2008 Joint Annual Conference, International Society for Environmental Epidemiology and International Society of Exposure Analysis (ISEE/ISEA). Oct. 12-16, Pasadena, California, USA

2007 Bone Lead and Endogenous Exposure among an Environmentally Exposed Elderly Population: the Normative Aging Study, The 17th Annual Conference of International Society of Exposure Analysis (ISEA), Oct.14-18, 2007, Durham, NC, USA

2005 Dosimetry Study for a New in-vivo X-ray fluorescence (XRF) Bone Lead Measurement System, The 6th Industrial Radiation and Radioisotope Measurement Applications (IRRMA-VI), Jun.20-24, 2005, Hamilton, Canada

2004 x-ray Fluorescence Data in the Study of Human Bone Lead Metabolism, The European Conference on X-ray Spectrometry (EXRS) June 6-11, 2004, Alghero, Italy

2002 Improvement for the in vivo Measurement of Lead in Bone, The 5th International Topical Meeting on Industrial Radiation and Radioisotope Measurement Applications (IRRMA-V), Jun.9-14, 2002, Bologna, Italy

1999 Study on Air Pollution in Beijing Major Industrial Areas Using Multielements in Biomonitors and NAA Techniques, Utilization of the Research Reactor, Feb. 1999, Yogyakarta, Indonesia

1998 Preliminary Study on Relationship between Osteoporosis and Trace Elements with Rat Models, The 6th Nuclear Analytical Methods in Life Sciences (NAMLS-6), Oct.26-30, 1998, Beijing, China

Invited lectures

2008 Bone Lead and Endogenous Exposure, Lead Collaborative Consortium, Jun2-3, Hamilton, ON, Canada

2008 The Study of a New X-ray Fluorescence (XRF) System for Non-invasive in vivo Bone Lead Measurement, Southern Illinois University Carbondale, IL, Mar.17, 2008

2008 Trabecular Bone Microdosimetry for alpha and beta Particles Incorporated in Bone Remodeling Process, McMaster University, Hamilton, ON, Canada, Mar.6, 2008

2007 The Application of X-ray Fluorescence (XRF) and Neutron Activation Analysis (NAA) in in-vivo Measurement of Metals, Henry Ford Health System, Detroit, MI, Nov.9, 2007

2007 Lead Exposure Assessment for Children with an Advanced K X-ray Fluorescence (KXRF) Bone Lead Measurement System, University of Michigan School of Public Health, Ann Arbor, MI, Nov.7, 2007

2006 Lead Exposure Assessment for Children with a State-of-Art K X-ray Fluorescence (KXRF) Bone Lead Measurement System, Children's Hospital, Boston, MA, May.19, 2006

2005 The Study of a New X-ray Fluorescence (XRF) System for the in vivo Bone Lead Measurement, Harvard School of Public Health, Boston, MA, Apr.5, 2005

2004 Development of an X-ray Fluorescence (XRF) System for the in vivo Bone Lead Measurement, University of Western Ontario, London, ON, Canada, Jul.6, 2004

Representative Publications

Nie H, Sanchez B, Elissa Wilker, Marc Weisskopf, Joel Schwartz, Hu H. Bone Lead and Endogenous Exposure among an Environmentally Exposed Elderly Population: the Normative Aging Study, Journal of Occupational and Environmental Medicine, 51(2009)848-857, 2009

Weisskopf MG, Jain N, Nie H, Sparrow D, Vokonas P, Schwartz J, Hu H. A Prospective Study of Bone Lead Concentration and Death from All Causes, Cardiovascular Disease, and Cancer in the VA Normative Aging Study. Circulation, in press

Nie H, Richardson RB. Radiation Dose and Absorbed Fractions to Marrow Stem Cells from 3H, 14C, and Selected alpha-emitters Incorporated in Bone Remodeling Compartment. Physics in Medicine and Biology, 54(2009)963-979

Nie H, Hu H, Chettle DR. Application and Methodology of in-vivo K X-ray Fluorescence of Pb in Bone, X-ray Spectrometry, 37(2008)69-75

Nie H, Chettle DR, Luo LQ, O'Meara JM. Dosimetry Study for a New in-vivo X-ray Fluorescence (XRF) Bone Lead Measurement System, Nuclear Instruments and Methods in Physics Research B, 263(2007)225-230

Popovic M, Nie H, Chettle DR, McNeill FE, Kaye WE, Lee V, Stokes L. Left-censoring: A Second Look at Bone Lead Concentration Measurements, Physics in Medicine and Biology, 52(2007)5369-5378

Richardson RB, Nie H, Chettle DR. Monte Carlo Simulations of Trabecular Bone Remodelling and Absorbed Dose Coefficients for Tritium and Carbon-14, Radiation Protection Dosimetry, 127(2007)158-162

Nie H, Chettle DR, Luo LQ, O'Meara JM. In-vivo Investigation of a New 109Cd gamma-ray Induced K-XRF Bone Lead Measurement System, Physics in Medicine and Biology, 51(2006)351-360

Nie H, Chettle DR, Webber CE, Brito JAA, O'Meara JM, McNeill FE. The Study of Age Influence on Human Bone Lead Metabolism by Using a Simplified Model and X-ray Fluorescence Data, The Journal of Environmental Monitoring 7(2005)1069-1073

Nie H, Chettle DR, McNeill FE, O'Meara JM. An Investigation of 109Cd Induced K-XRF Lead Measurement Calibration, Physics in Medicine and Biology 49 (2004) N325-334