Ulrike Dydak, Ph.D. Assistant Professor of Health Sciences Phone: (765) 494-0550 Fax: (765) 496-1377 E-mail: udydak@purdue.edu Full directory listing

Education

Research: Magnetic Resonance Spectroscopy

Dr. Dydak's research interest is in the area of in vivo Magnetic Resonance Imaging (MRI) and focuses on the investigation of human in vivo metabolism by means of Magnetic Resonance Spectroscopy (MRS). She has expertise in the development of new MRS pulse sequences, and in the design and implementation of clinical MRI/MRS studies. Dr. Dydak holds an adjunct appointment at the Indiana Institute for Biomedical Imaging Sciences (IIBIS) at IU School of Medicine, where part of her research lab is located. Her current research topics comprise:

• development of fast spectroscopic imaging (MRSI) techniques
• in vivo GABA measurements by MRS
• parallel multi-nuclear MRSI (31P MRS)
• MRS studies exploring manganese neurotoxicity
• High resolution 1H MRS in the rat brain

In collaboration with IU School of Medicine, she is currently involved in the following projects:

• comparison of different fast MRSI techniques for applications in brain and breast
• multi-channel 31P MRSI for the assessment of radiation treatment response in liver cancer
• metabolic changes in untreated patients with bipolar disorder
• GABA measurements in patients with panic disorder
• Neurotransmitter changes due to exposure to manganese
• 3D MRSI exploring metabolic changes after chemotherapy in breast cancer

Teaching

• HSCI 514 - Radiation Instrumentation Lab (spring)
• HSCI 534 - Applied Health Sciences (fall)

Representative Publications

Northoff G, Walter M, Schulte RF , Beck J, Dydak U, Henning A, Boeker H, Grimm S, Boesiger P. GABA concentration in the human anterior cingulate cortex predicts negative BOLD response in fMRI. Nature Neuroscience, 2007

Schoonman GG, Sandor PS, Nirkko AC, Lange T, Jaermann T, Dydak U, Kremer C, Ferrari MD, Boesiger P, Baumgartner RW. Hypoxia-induced acute mountain sickness is associated with intracellular cerebral edema: a 3T magnetic resonance imaging study. J Cereb Blood Flow Metab, advance online publication 23 May 2007.

Dydak U, Schär M. MR Spectroscopy and Spectroscopic Imaging: Comparing 3.0T versus 1.5T. Review Article. Neuroimaging Clin N Am 16(2):269-283 (2006).

Dydak U, Mueller S, Sandor PS, Meier D, Boesiger P, Jung HH. Cerebral Metabolic Alterations in McLeod Syndrome. Eur Neurol 56(1):17-23 (2006).

Dydak U, Meier D, Lamerichs R, Boesiger P. Trading Spectral Separation at 3T for Acquisition Speed in Multi Spin-Echo Spectroscopic Imaging. AJNR Am J Neuroradiol. 27(7):1441-6 (2006).

Lange T, Dydak U, Roberts TP, Rowley HA, Bjeljac M, Boesiger P. Pitfalls in Lactate Measurements at 3T. AJNR Am J Neuroradiol. 27(4):895-901 (2006).

Lange T, Trabesinger AH, Schulte RF, Dydak U, Boesiger P. Prostate spectroscopy at 3 Tesla using two-dimensional S-PRESS. Magn Reson Med. 56(6):1220-8 (2006).

Sandor PS, Dydak U, Schoenen J, Kollias SS, Hess K, Boesiger P, Agosti M. MR-Spectroscopic Imaging during visual stimulation in subgroups of migraine with aura, Cephalalgia 25(7):507-518 (2005).

Dydak U, Pruessmann KP, Weiger M, Tsao J, Meier D, Boesiger P. Parallel Spectroscopic Imaging with Spin-Echo Trains, Magn Reson Med. 50(1): 196-200 (2003).

Dydak U, Weiger M, Pruessmann KP, Meier D, Boesiger P. Sensitivity-Encoded Spectroscopic Imaging, Magn Reson Med. 46(4): 713-722 (2001).