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School of Health Sciences Personnel - Ulrike Dydak

Ulrike Dydak, Ph.D.
Associate Professor of Health Sciences
Phone: 765-494-0550
Fax: 765-496-1377
E-mail: udydak@purdue.edu
Lab webpage: http://purcell.healthsciences.purdue.edu/mrslab/

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Picture of Ulrike Dydak

Education

M.S. - Physics - University of Vienna, Austria (1996)
M.S. (postgraduate diploma) - Medical Physics - ETH Zurich, Switzerland (2000)
Ph.D. - Physics - ETH Zurich, Switzerland (2002)

Research: Magnetic Resonance Imaging / Magnetic Resonance Spectroscopy

Dr. Dydak’s research is focused on the development of Magnetic Resonance Spectroscopy (MRS) for the noninvasive in-vivo assessment of biologically important molecules in normal biochemical processes and the disruption of these molecules in human disease and disorders.  A long-term goal of this research is to translate the knowledge gained through the development and application of novel MRS methods into viable clinical diagnostic procedures that aid in disease detection as well as assessment of treatment response. Special emphasis of her work lies on the development of the in vivo detection and quantification of γ-aminobutyric acid (GABA), an inhibitory neurotransmitter, to study manganese-induced parkinsonian neurotoxicity. A second focus lies on the development of whole-liver phosphorous (31P) magnetic resonance spectroscopic imaging of the human liver to improve treatment monitoring in liver cancer. Dr. Dydak holds an adjunct appointment at the Department of Radiology and Imaging Sciences at IU School of Medicine, where part of her research lab is located. MRI/MRS techniques used, optimized or developed in the Dydak lab comprise:

  • Neuroimaging to study occupational manganese neurotoxicity
  • Quantification of in vivo GABA measurements by MRS
  • GABA mapping by MEGA spectroscopic imaging
  • Fast 3D multi-nuclear MRSI (31P MRS) to monitor response to radiation treatment in the human liver
  • High resolution 1H MRS in the rat brain

Using these techniques, Dr. Dydak's group is currently involved in the following collaborative projects:

  • Neuroimaging of Manganese Neurotoxicity in Welders
  • GABA and Glu as marker of disease progression in Parkinson Disease
  • Associations of Brain GABA levels with fine motor skills
  • Brain GABA changes in patients with Essential Tremor 
  • Brain GABA changes in bruxism
  • multi-channel 31P MRSI for the assessment of radiation treatment response in liver cancer

Lab Members:

Teaching

  • HSCI 312 - Radiation Science Fundamentals (fall)
  • HSCI 590 - Molecular Imaging - Part I: Magnetic Resonance Spectroscopy (spring)
  • HSCI 690 – MRI Quality Assurance (Internship)

Honors and Credentials

  • 2011 Outstanding New Environmental Scientist (ONES) Award, NIEHS
  • 2011 Robert R. Landolt Excellence in teaching Award
  • 2009 Molecular Imaging Travel Award, Radiological Society of Noth America (RSNA)
  • 2008 Magna Cum Laude Award for Educational Exhibit, Radiological Society of North America (RSNA)

Grants

  • NIH/NIEHS ONES R01 ES020529 (Dydak), Neuroimaging for Early Diagnosis of Manganese Toxicity in Humans and Rodents, 2011-2016
  • NIH/NINDS R01 NS085136 (Louis), In Vivo Quantification of Cerebellar GABA and NAA in Essential Tremor, 2013-2018
  • Purdue Center for Cancer Research Challenge grant (Dydak), 3D 31P MRSI of Human Liver: A Spatially-resolved Study of Normal and Malignant Tissue Repsonse to Radiation Therapy, 2012-2013
  • Purdue Research Foundation Award (Dydak), GABA MR Spectroscopy as a Potential Biomarker for Parkinson Disease, 2013-2014

Administration and Committee Work

  • Chair, Website committee, School of Health Sciences
  • Member, Graduate Committee, School of Health Sciences
  • Member, Research Advisory Council, College of Health and Human Sciences

Representative Publications

Long Z, Medlock C, Dzemidzic M, Shin YW, Goddard A, Dydak U (2013). Decreased GABA levels in Anterior Cingulate Cortext/Medial Prefrontal Cortex in Panic Disorder. Prog NeuroPsychopharmacol Biol Psychiatry. Epub 2013 Feb 4., doi:pii: S0278-5846(13), PMID: 23391588

Shin YW, Dzemidzic M, Jo HJ, Long Z, Medlock C, Dydak U, Goddard AW (2013). Increased resting-state connectivity between the anterior cingulate cortex and the precuneus in panic disorder. J Affect Disord. 2013 May 17. doi:pii: S0165-0327(13)00299-1. 10.1016/j.jad.2013.04.026, PMID: 23688914

Panda A, Jones S, Raghavan RS, Sandrasegaran K, Bansal N, Dydak U (2012). Phosphorus Liver MRSI at 3T Using a Novel Dual Tuned 8-Channel 31P/1H Coil. Magnetic Resonance in Medicine 2012. Epub Jan 27 2012 

Racette B.A., Aschner M, Guilarte TR, Dydak U, Criswell SR, Zheng W (2012). Pathophysiology of Manganese-Associated Neurotoxicity. Neurotoxicology 33(4):881-6. PMID: 22202748  

Dydak U, Jiang YM, Long LL, Zhu H, Chen J, Li WM, Edden RAE, Hu S, Fu X, Long Z, Meier D, Harezlak J, Aschner M, Murdoch JB, Zheng W (2011). In Vivo Measurement of Brain GABA Concentrations by Magnetic Resonance Spectroscopy in Smelters Occupationally Exposed to Manganese. Environ Health Perspect.119:219-224, 2011

Zheng W, Fu X, Dydak U, Cowan DM (2011). Biomarkers of Manganese Intoxication. Neurotoxicology 32:1-8, 2011

Northoff G, Walter M, Schulte RF , Beck J, Dydak U, Henning A, Boeker H, Grimm S, Boesiger P. GABA concentration in the human anterior cingulate cortex predicts negative BOLD response in fMRI. Nature Neuroscience, 2007
 
Schoonman GG, Sandor PS, Nirkko AC, Lange T, Jaermann T, Dydak U, Kremer C, Ferrari MD, Boesiger P, Baumgartner RW. Hypoxia-induced acute mountain sickness is associated with intracellular cerebral edema: a 3T magnetic resonance imaging study. J Cereb Blood Flow Metab, advance online publication 23 May 2007.
 
Dydak U, Schär M. MR Spectroscopy and Spectroscopic Imaging: Comparing 3.0T versus 1.5T. Review Article. Neuroimaging Clin N Am 16(2):269-283 (2006).
 
Dydak U, Mueller S, Sandor PS, Meier D, Boesiger P, Jung HH. Cerebral Metabolic Alterations in McLeod Syndrome. Eur Neurol 56(1):17-23 (2006).
 
Dydak U, Meier D, Lamerichs R, Boesiger P. Trading Spectral Separation at 3T for Acquisition Speed in Multi Spin-Echo Spectroscopic Imaging. AJNR Am J Neuroradiol. 27(7):1441-6 (2006).
 
Lange T, Dydak U, Roberts TP, Rowley HA, Bjeljac M, Boesiger P. Pitfalls in Lactate Measurements at 3T. AJNR Am J Neuroradiol. 27(4):895-901 (2006).
 
Lange T, Trabesinger AH, Schulte RF, Dydak U, Boesiger P. Prostate spectroscopy at 3 Tesla using two-dimensional S-PRESS. Magn Reson Med. 56(6):1220-8 (2006).
 
Sandor PS, Dydak U, Schoenen J, Kollias SS, Hess K, Boesiger P, Agosti M. MR-Spectroscopic Imaging during visual stimulation in subgroups of migraine with aura, Cephalalgia 25(7):507-518 (2005).
 
Dydak U, Pruessmann KP, Weiger M, Tsao J, Meier D, Boesiger P. Parallel Spectroscopic Imaging with Spin-Echo Trains, Magn Reson Med. 50(1): 196-200 (2003).
 
Dydak U, Weiger M, Pruessmann KP, Meier D, Boesiger P. Sensitivity-Encoded Spectroscopic Imaging, Magn Reson Med. 46(4): 713-722 (2001).

Curriculum Vitae

Click here for a full CV for Ulrike Dydak. (an Adobe Acrobat file)

This record was last updated on May 23, 2014 at 7:59 AM
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