Gary P. Carlson, Ph.D. Professor of Toxicology Adjunct Professor of Pharmacology and Toxicology - Indiana University School of Medicine (Lafayette Center) Phone: (765) 494-1412 Fax: (765) 496-1377 E-mail: gcarlson@purdue.edu Full directory listing

Education

Research: Toxicology; relationship between the metabolism of chemicals and their toxicities

Dr. Carlson is examining the relationship between the metabolism of chemicals and their toxic actions. This includes an interest in both activation and detoxification pathways in the liver and other target organs. Current studies utilize a variety of techniques ranging from isolated cells to whole animals to examine the biochemical mechanisms by which chemical agents exert their toxic and carcinogenic actions. Particular attention focuses on the lung as both a target tissue and a major organ of bioactivation of chemicals that produce either pneumotoxicity and/or systemic toxicity. Emphasis is placed on substrates of cytochrome P450 2E1 which is involved in the activation of a number of toxic and carcinogenic small molecular weight compounds such as ethyl carbamate (urethane), styrene, carbon tetrachloride and benzene. Of additional interest is the effect other agents such as ethanol and pyridine have in modifying the metabolism and subsequent toxicity of these compounds leading to chemical-chemical interactions.

Honors and Credentials

• Society of Toxicology Education Award, 2000
• School of Health Sciences Excellence in Teaching Award, 2000
• School of Health Sciences Excellence in Teaching Award, 2001
• National Associate of the National Academies, 2002 - lifetime

Administration and Committee Work

• Chair, Purdue Animal Care and Use Committee
• Institutional Biosafety Committee
• Purdue University Hazards Management Oversight Committee

Representative Publications

Harvilchuck, J.A. and Carlson, G.P. Effect of multiple doses of styrene and R-styrene oxide on CC10, BAX, and BCL-2 expression in isolated Clara cells of CD-1 mice. Toxicology 259: 149-152, 2009.

Meszka-Jordan, A., Mahlapuu, R., Soomets, U., and Carlson, G.P. Oxidative stress due to (R)-styrene oxide exposure and the role of antioxidants in non-Swiss albino (NSA) mice. J. Toxicol. Environ. Health, Part A, 72: 642-650, 2009.

Rademaker, A.M., McGlothlin, J.D., Moenning, J.E., Bagnoli, M., Carlson, G.P., and Griffin, C. Evaluation of two nitrous oxide scavenging systems using infrared thermography and real-time air analysis to visualize and control fugitive emissions. J. Amer. Dental Assoc. 140: 190-199, 2009.

Carlson, G.P. Critical appraisal of the expression of cytochrome P450 enzymes in human lung and evaluation of the possibility that such expression provides evidence of potential styrene tumorigenicity in humans. Toxicology 254: 1-10, 2008.

Harvilchuck, J.A., Zurbrugg, R.J. and Carlson, G.P. CC10 mRNA and protein expression in Clara cells of CD-1mice following exposure to styrene or its metabolites styrene oxide or 4-vinylphenol. Toxicology Lett. 183: 28-35, 2008.

Wagoner, L., McGlothlin, J., Chung, K., Strickland, E., Zimmerman, N., and Carlson, G.P., 2007. Evaluation of noise attenuation and verbal communication capabilities using three ear insert hearing protection systems among airport maintenance personnel. J. Occup. Environ. Hygiene 4: 114-122, 2007.

Pu, X., Lee, L.S., Galinsky, R.E., and Carlson, G.P. Bioavailability of 2,3 ,4,4 ,5-pentachlorobiphenyl (PCB118) and 2,2 ,5,5 -tetrachlorobiphenyl (PCB52) from soils using a rat model and a physiologically based extraction test. Toxicology 217: 14-21, 2006.

Harvilchuck, J.A. and Carlson, G.P. Comparison of styrene and its metabolites styrene oxide and 4-vinylphenol on cytotoxicity and glutathione depletion in Clara cells of mice and rats. Toxicology 227: 165-172, 2006.

Carlson, G.P., Turner, M., Mantick, N.A. Effects of styrene and styrene oxide on glutathione-related antioxidant enzymes. Toxicology 227: 217-226, 2006.

Cruzan, G., Carlson, G.P., Turner, M., and Mellert, W. Ring-oxidized metabolites of styrene contribute to styrene-induced Clara cell toxicity in mice. J. Toxicol. Environ. Health 68: 229-237, 2005.