School of Health Sciences

Huiling (Linda) Nie, MSc. PhD., Assistant Professor of Health Sciences Assistant Professor Phone: 765-494-2625 E-mail: hnie@purdue.edu Full directory listing

Education

Research: Medical Physics, Health Physics, Radiation Sciences, Environmental Health

Current research:

• Development of new biomarkers for metal exposure assessment; human body composition

          X-ray Fluorescence (XRF) technology for in vivo quantification of elements in human body; Neutron activation analysis (NAA) technology for in vivo quantifications of elements in human body; Associated particle neutron imaging technology for early diagnose of critical diseases; etc.

• Bone microdosimetry for alpha and beta particles
• Exposure to heavy metals and helath outcomes for children and adults
• Biology effects of low-dose radiation and low-dose heavy metal exposures
• Radiation shielding and dose calculation software development

Interests

MAJOR RESEARCH INTERESTS:

• The application of nuclear physics in environmental health. Instrumentation and methods development for the in vivo measurement of lead, cadmium, arsenic, mercury, and other metals. Systems and methodology for tracing environmental sources of metals and other pollutants.
• The application of nuclear physics in medicine. Study of radiation transport and dose distributions in biologic tissue and material. Basic research in radiotherapy and nuclear medicine.
• Radiation protection. Radiation dosimetry and microdosimetry. Development of compartmental and bio-kinetic models to assess radiation dose to radionuclide therapy patients, radiation workers, and the general population.
• Radiobiology and toxicology. Investigation of low-dose radiation effects and low-dose metal toxicity at the cellular and DNA level. Effect of radiation and toxic chemical on various end points such as cell survival, DNA damage, and gene expressions.
• General nuclear physics applications in other fields.

Teaching

Applied Health Physics, HSCI534
Radiation Instrumentation Laboratory, HSCI514
Radiological Emergency Management, HSCI390

Graudate Students
as major advisor:
Steven Sanchez; James T Dant; Yingzi Liu; Aaron Specht (undergraduate)

as a committee member:
Sandra Cole; Xin Lu; Patrick Meek; Ashuaman Panda;
Christina Peace; Eric Peppin; Seth Streitmatter; Kent Wong;
Victor Yu; Qingya Zhao

Presentations

International conferences

• Annual HPS meeting, Purdue HP program representative, Jun.26-30, 2011, West Palm Beach, FL
• Validation of a portable x-ray fluorescence (XRF) technology to quantify lead in bone in vivo, SOT Annual meeting, Mar.6-10, 2011, Washington D.C.
• Bone and Blood Lead Levels as Predictors of Late Neurodevelopment in Lead Poisoned Children, Pediatric Academic Societies (PAS) Annual Meeting, May.1-4, 2010, Vancouver, Canada
• Development of a Portable XRF System for In vivo Quantification of Lead (Pb) in Bone, 2010 SOT Annual Meeting, Mar.7-11, Salt Lake City, Utah
• Accuracy and Precision of an Advanced in vivo K-x Ray Fluorescence (KXRF) Bone Lead Measurement System. 2008 Joint Annual Conference, International Society for Environmental Epidemiology and International Society of Exposure Analysis (ISEE/ISEA). Oct. 12-16, Pasadena, California, USA
• Bone Lead and Endogenous Exposure among an Environmentally Exposed Elderly Population: the Normative Aging Study, The 17th Annual Conference of International Society of Exposure Analysis (ISEA), Oct.14-18, 2007, Durham, NC, USA
• Dosimetry Study for a New in-vivo X-ray fluorescence (XRF) Bone Lead Measurement System, The 6th Industrial Radiation and Radioisotope Measurement Applications (IRRMA-VI), Jun.20-24, 2005, Hamilton, Canada
• x-ray Fluorescence Data in the Study of Human Bone Lead Metabolism, The European Conference on X-ray Spectrometry (EXRS) June 6-11, 2004, Alghero, Italy
• Improvement for the in vivo Measurement of Lead in Bone, The 5th International Topical Meeting on Industrial Radiation and Radioisotope Measurement Applications (IRRMA-V), Jun.9-14, 2002, Bologna, Italy
• Study on Air Pollution in Beijing Major Industrial Areas Using Multielements in Biomonitors and NAA Techniques, Utilization of the Research Reactor, Feb. 1999, Yogyakarta, Indonesia
• Preliminary Study on Relationship between Osteoporosis and Trace Elements with Rat Models, The 6th Nuclear Analytical Methods in Life Sciences (NAMLS-6), Oct.26-30, 1998, Beijing, China

 Invited lectures

• Noninvasive In Vivo Quantification of Lead in Bone, Shanghai Institute for Pediatric Research, Xinhua Hospital, Shanghai, China, Dec.30, 2010
• Noninvasive In Vivo Quantification of Metals in Human Tissues, IU School of Medicine, Indianapolis, IN, Jul.7 2010
• Bone and Blood Lead Levels and CBLI as Predictors of Late Neurodevelopment in Lead Poisoned Children, Lead Collaborative Consortium, McMaster University, Hamilton, ON, Canada, Jun.3-4 2010
• Noninvasive In Vivo Exposure Assessment of Metals, NIOSH research center seminar, University of Michigan School of Public Health, Ann Arbor, Michigan, Mar.26 2009
• Trabecular Bone Microdosimetry for 3H, 14C, and Selected alpha-emitters Incorporated in Bone Remodeling Process, and Three Other Projects, Purdue School of Nuclear Engineering, West Lafayette, IN, Mar.30 2009
• Development and Application of a New XRF in vivo Bone Lead Measurement System, and Three Other Projects in Radiation Dosimetry and Nuclear Instrumentation, Purdue School of Health Sciences, West Lafayette, IN, Feb.24 2008
• Development and Application of a New X-ray Fluorescence (XRF) System for in vivo Bone Lead Measurement, and Three Other Projects, East Carolina University, Greenville, NC, Dec.9 2008
• Development and Application of a New X-ray Fluorescence (XRF) System for in vivo Bone Lead Measurement, and Three Other Projects, University of Michigan, Ann Arbor, MI, Dec.5 2008
• Trabecular Bone Microdosimetry for 3H, 14C, and Selected alpha-emitters Incorporated in Bone Remodeling Process, Virginia Commonwealth University Medical Center, Richmond, VA, Aug.27 2008
• Bone Lead and Endogenous Exposure, Lead Collaborative Consortium, Hamilton,ON, Canada, Jun.2-3 2008
• The Study of a New X-ray Fluorescence (XRF) System for Non-invasive in vivo Bone Lead Measurement, Southern Illinois University Carbondale, IL, Mar.17 2008
• Trabecular Bone Microdosimetry for alpha and beta Particles Incorporated in Bone Remodeling Process, McMaster University, Hamilton, ON, Canada, Mar.6 2007
• The Application of X-ray Fluorescence (XRF) and Neutron Activation Analysis (NAA) in in-vivo Measurement of Metals, Henry Ford Health System, Detroit, MI, Nov.9 2007
•  Lead Exposure Assessment for Children with an Advanced K X-ray Fluorescence (KXRF) Bone Lead Measurement System, University of Michigan School of Public Health, Ann Arbor, MI, Nov.7 2006
• Lead Exposure Assessment for Children with a State-of-Art K X-ray Fluorescence (KXRF) Bone Lead Measurement System, Children's Hospital, Boston, MA, May.19 2005
• The Study of a New X-ray Fluorescence (XRF) System for the in vivo Bone Lead Measurement, Harvard School of Public Health, Boston, MA, Apr.5 2005
• The Study of a New X-ray Fluorescence (XRF) System for the in vivo Bone Lead Measurement, Hamilton Regional Cancer Center, Hamilton, ON, Canada, Mar.23 2004
• Development of an X-ray Fluorescence (XRF) System for the in vivo Bone Lead Measurement, University of Western Ontario, London, ON, Canada, Jul.6 2004
     

Representative Publications

Nie LH, Wright RO, Bellinger D, Hussain J, Amarasiriwardena C, Chettle DR, Pejovic-Milic A, Woolf A, Shannon M. Blood Lead Levels and CBLI as Predictors of Late Neurodevelopment in Lead Poisoned Children, Biomarkers, 16(2011)517-524

Eum KD, Nie LH, Schwartz J, Vokonas PS, Sparrow D, Hu H, Weisskopf MG. Prospective Cohort Study of Lead Exposure and Electrocardiographic Conduction Disturbances in the Department of Veterans Affairs Normative Aging Study. Environmental Health Perspect, 119(2011)940-944

Nie LH, Sanchez S, Grodzins L, Cleveland R, Weisskopf MG. In Vivo Quantification of Lead in Bone with a Portable XRF System - Methodology and Feasibility, Physics in Medicine and Biology, 56(2011)N39-51
 
Nie H, Sanchez B, Elissa Wilker, Marc Weisskopf, Joel Schwartz, Hu H. Bone Lead and Endogenous Exposure among an Environmentally Exposed Elderly Population: the Normative Aging Study, Journal of Occupational and Environmental Medicine, 51(2009)848-857, 2009
 
Weisskopf MG, Jain N, Nie H, Sparrow D, Vokonas P, Schwartz J, Hu H. A Prospective Study of Bone Lead Concentration and Death from All Causes, Cardiovascular Disease, and Cancer in the VA Normative Aging Study. Circulation, 120(2009)1056-1064
 
Nie H, Richardson RB. Radiation Dose and Absorbed Fractions to Marrow Stem Cells from 3H, 14C, and Selected alpha-emitters Incorporated in Bone Remodeling Compartment. Physics in Medicine and Biology, 54(2009)963-979
 
Nie H, Hu H, Chettle DR. Application and Methodology of in-vivo K X-ray Fluorescence of Pb in Bone, X-ray Spectrometry, 37(2008)69-75
 
Nie H, Chettle DR, Luo LQ, O'Meara JM. Dosimetry Study for a New in-vivo X-ray Fluorescence (XRF) Bone Lead Measurement System, Nuclear Instruments and Methods in Physics Research B, 263(2007)225-230
 
Richardson RB, Nie H, Chettle DR. Monte Carlo Simulations of Trabecular Bone Remodelling and Absorbed Dose Coefficients for Tritium and Carbon-14, Radiation Protection Dosimetry, 127(2007)158-162
 
Nie H, Chettle DR, Luo LQ, O'Meara JM. In-vivo Investigation of a New 109Cd gamma-ray Induced K-XRF Bone Lead Measurement System, Physics in Medicine and Biology, 51(2006)351-360
 
Nie H, Chettle DR, Webber CE, Brito JAA, O'Meara JM, McNeill FE. The Study of Age Influence on Human Bone Lead Metabolism by Using a Simplified Model and X-ray Fluorescence Data, The Journal of Environmental Monitoring 7(2005)1069-1073
 
Nie H, Chettle DR, McNeill FE, O'Meara JM. An Investigation of 109Cd Induced K-XRF Lead Measurement Calibration, Physics in Medicine and Biology 49 (2004) N325-334