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School of Health Sciences Personnel - Huiling (Linda) Nie

Huiling (Linda) Nie, MSc. PhD., Assistant Professor of Health Sciences
Assistant Professor
Phone: 765-494-2625

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Picture of Huiling (Linda) Nie


B.Sc., 1996, Physics, Zhongnan University of Technology
M.Sc.,2001, Medical Physics, McMaster University
PhD, 2005, Medical Physics, McMaster University
PostDoc, 2009, Nuclear Instrumentation/Environmental Health/Epidemiology, Harvard University

Research: Medical Physics, Health Physics, Radiation Sciences, Environmental Health

Current research projects:

  • Development and Validation of Non-invasive In Vivo Neutron Acitivation Analysis (NAA) Technologies for Elemental Quantification and Analysis in Human Tissues
  • Development and Validation of Non-invasive In Vivo X-ray Fluorescence (XRF) Technologies for Elemental Quantification and Analysis in Human Tissues
  • Development and Validation of an Associated Particle Neutron Elemental Imaging (APNEI) System for Medical Diagnostics
  • Development of a Compact Neutron Generator Based Boron Neutron Capture Therapy (BNCT) System
  • Application of Novel Neutron and X-ray Technologies in Occupational/Environmental Health and Medicine
  • Biological Effects of Radiation Exposure and Combined Exposures of Metals and Radiation
  • Bone Microdosimetry for Bone and Bone Marrow Seeking Alpha and Beta-emitters Using a Novel Trabecular Bone Model



  • The application of nuclear physics in environmental health. Instrumentation and methods development for the in vivo measurement of lead, cadmium, arsenic, mercury, and other metals. Systems and methodology for tracing environmental sources of metals and other pollutants.
  • The application of nuclear physics in medicine. Study of radiation transport and dose distributions in biologic tissue and material. Basic research in radiotherapy and nuclear medicine.
  • Radiation protection. Radiation dosimetry and microdosimetry. Development of compartmental and bio-kinetic models to assess radiation dose to radionuclide therapy patients, radiation workers, and the general population.
  • Radiobiology and toxicology. Investigation of low-dose radiation effects and low-dose metal toxicity at the cellular and DNA level. Effect of radiation and toxic chemical on various end points such as cell survival, DNA damage, and gene expressions.
  • General nuclear physics applications in other fields.

Service and Engagement

  • Chair, Nomination and Awards Committee, School of Health Sciences
  • Faculty Advisor, Health Physics Society Purdue Branch


Applied Health Physics, HSCI534
Radiation Instrumentation Laboratory, HSCI514
Radiological Emergency Management, HSCI390

Postdoctoral Research Associate:

Farshad Mostafaei

Graduate Students:

Yingzi Liu; Aaron Specht; Patrick Byrne; Daniel Sowers; Michael Abel; Lee Alleman; Ming-Jung Hsieh; Yufei Wang

Undergraduate Students:

Scott Blake, Austin Trout, Nikola Plavsa


James T Dant; Steven L Sanchez; Gopal Subedi; Jacob Wilson

Representative Publications

Specht A, Weisskopf M, Nie LH, Portable XRF Technology to Quantify Pb in Bone In Vivo, 2014, Biomarkes, in press

Liu Y, Byrne P, Wang H, Koltick D, Zheng W, Nie LH, A Compact DD Neutron Generator-based NAA System to Quantify Manganese (Mn) in Bone In Vivo. Physiological Measurement, 35(2014)1899-1911

Freeman JL, Weber GJ, Peterson SM, Nie LH, Embryonic Ionizing Radiation Exposure Results in Expression Alterations of Genes Associated with Cardiovascular and Neurological Development, Function, and Disease and Modified Cardiovascular Function in Zebrafish, Frontiers in Genetics, 122(2014)229-334

O'Neal SL, Hong L, Fu S, Jiang W, Jones A, Nie LH, Zheng W, Manganese Accumulation in Bone Following Chronic Exposure in Rats: Steady-state Concentration and Half-life in Bone, Toxicol Lett, 229(2014)93-100

Eum KD, Weisskopf MG, Nie LH, Hu H, Korrick SA. Cumulative Lead Exposure and Age at Menopause in the Nurses' Health Study Cohort. Environmental Health Perspect. 122(2014)229-234

Liu Y, Koltick D, Byrne P, Zheng W, and Nie LH, Development of a Transportable Neutron Activation Analysis System to Quantify Mn in Bone In Vivo - Feasibility and Methodology, Physiological Measurement, 34(2013)1593-1609

Dant JT, Richardson R, Nie LH, Monte Carlo Simulation of Age-dependent Radiation Dose from Alpha- and Beta-emitting Radionuclides to Critical Trabecular Bone and Bone Marrow Targets, Physics in Medicine and Biology, 58(2013)3301-3319

Koltick D and Nie LH, Associated Particle Neutron Imaging for Elemental Imaging in Medical Diagnostics, IEEE Nuclear Transactions, 60(2013)824-829

Grashow R, Miller MW, McKinney A, Nie LH, Sparrow D, Hu H, Weisskopf MG, Lead Exposure and Fear-potentiated Startle in the VA Normative Aging Study: A Pilot Study of a Novel Physiological Approach to Investigating Neurotoxicant Effects, Neurotoxicology and Teratology, 38(2013)21-28

Nie LH, Wright RO, Bellinger D, Hussain J, Amarasiriwardena C, Chettle DR, Pejovic-Milic A, Woolf A, Shannon M. Blood Lead Levels and CBLI as Predictors of Late Neurodevelopment in Lead Poisoned Children, Biomarkers, 16(2011)517-524

Eum KD, Nie LH, Schwartz J, Vokonas PS, Sparrow D, Hu H, Weisskopf MG. Prospective Cohort Study of Lead Exposure and Electrocardiographic Conduction Disturbances in the Department of Veterans Affairs Normative Aging Study. Environmental Health Perspect, 119(2011)940-944

Nie LH, Sanchez S, Grodzins L, Cleveland R, Weisskopf MG. In Vivo Quantification of Lead in Bone with a Portable XRF System - Methodology and Feasibility, Physics in Medicine and Biology, 56(2011)N39-51
Nie H, Sanchez B, Elissa Wilker, Marc Weisskopf, Joel Schwartz, Hu H. Bone Lead and Endogenous Exposure among an Environmentally Exposed Elderly Population: the Normative Aging Study, Journal of Occupational and Environmental Medicine, 51(2009)848-857, 2009
Weisskopf MG, Jain N, Nie H, Sparrow D, Vokonas P, Schwartz J, Hu H. A Prospective Study of Bone Lead Concentration and Death from All Causes, Cardiovascular Disease, and Cancer in the VA Normative Aging Study. Circulation, 120(2009)1056-1064
Nie H, Richardson RB. Radiation Dose and Absorbed Fractions to Marrow Stem Cells from 3H, 14C, and Selected alpha-emitters Incorporated in Bone Remodeling Compartment. Physics in Medicine and Biology, 54(2009)963-979
Nie H, Hu H, Chettle DR. Application and Methodology of in-vivo K X-ray Fluorescence of Pb in Bone, X-ray Spectrometry, 37(2008)69-75
Nie H, Chettle DR, Luo LQ, O'Meara JM. Dosimetry Study for a New in-vivo X-ray Fluorescence (XRF) Bone Lead Measurement System, Nuclear Instruments and Methods in Physics Research B, 263(2007)225-230
Richardson RB, Nie H, Chettle DR. Monte Carlo Simulations of Trabecular Bone Remodelling and Absorbed Dose Coefficients for Tritium and Carbon-14, Radiation Protection Dosimetry, 127(2007)158-162
Nie H, Chettle DR, Luo LQ, O'Meara JM. In-vivo Investigation of a New 109Cd gamma-ray Induced K-XRF Bone Lead Measurement System, Physics in Medicine and Biology, 51(2006)351-360
Nie H, Chettle DR, Webber CE, Brito JAA, O'Meara JM, McNeill FE. The Study of Age Influence on Human Bone Lead Metabolism by Using a Simplified Model and X-ray Fluorescence Data, The Journal of Environmental Monitoring 7(2005)1069-1073
Nie H, Chettle DR, McNeill FE, O'Meara JM. An Investigation of 109Cd Induced K-XRF Lead Measurement Calibration, Physics in Medicine and Biology 49 (2004) N325-334

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This record was last updated on Nov 26, 2014 at 12:32 PM
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