Keith M. Stantz, Ph.D.
Associate Professor of Health Sciences Phone: 765-496-1874
Assistant Professor of Radiology, Indiana University School of Medicine
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EducationValparaiso University, Valparaiso, IN B.S Physics and EECE
Michigan State University, East Lansing, MI M.S Physics
Indiana University, Bloomington, IN Ph.D Physics
(Thesis: "Search for the lepton-family-number nonconserving decay μ->e+γ", Los Alamos National Laboratories, NM)
Research: Molecular and Physiological Imaging of Hypoxia and Cancer
Dr. Keith Stantz's research interests include: (1) developing photoacoustic computed tomographic (PCT) scanner and analytic methods for in vivo quantification of endogenous (hemoglobin) and exogenous (photoacoustic contrast agents) molecules, (2) developing a new PCT-S scanner for dynamic constrast-enhanced techniques (DCE-CT) for in vivo quantification of vascular physiology in mouse models of cancer, (3) discovering patterns of intra-tumor hemodynamics and oxygenation of cancer to different cancer angiogenic phenotypes, and (4) discovery of biological models linking anti-angiogenic therapeutic-driven hypoxia to cancer stem cells and metastasis.
Physiological Imaging using Dynamic Contrast-Enhance Imaging (DCE-CT)
- Quantify intra-tumor physiology (perfusion, PS, fp, fis)
- Influence of tumor angiogenic phenotype in cancer progression
- Monitor longitudinal intra-tumor hemodynamic response to anti-angiogenic therapy
Molecular Imaging using Photoacoustic CT-spectroscopy
- Quantify intra-tumor hemoglobin concentrations and oxygen saturation levels (SaO2)
- Quantify follicle stimulating hormone receptor (FSHR) expression and neuropilin receptor (NRP-1) in ovarian and breast tumors.
Modeling and Tumor Biology
- Mathematical models of intra-tumor hypoxia: models which fuse in vivo measurements of hemodynamic variables in order to measure tumor oxygenation and hypoxia.
- Explore properties of tumor hypoxia and influence on cancer stem cells prevalence
- Hypoxia Models in Radioresistent Tumors and their effects of Anti-angiogenic therapy on their Radiobiology and chemosensitivity
Service and Engagement
- HSCI 570 Diagnostic Medical Imaging (3 credit)
- HSCI 526 Principles of Health Physics and Dosimetry (3 credit)
- HSCI 101 Introduction to Health Sciences
- HSCI 202 Essentials of Environmental, Occupational, and Radiological Health Sciences
- HSCI 540 Radiation Biology
- HSCI 698 Seminars in Health Sciences
Honors and Credentials
Administration and Committee Work
Stantz KM, Liang Y, Hutchins, Gary; "Kinematic Modeling and Its Implication in Longitudinal Chemotherapy Study of Tumor Physiology: Ovarian Xenograft Mouse Model and Contrast-Enhanced Dynamic CT," Proc. SPIE Medical Imaging 5369:769-779, 2004.
Stantz KM, Liang Y, Li X, Kao C, Steinmetz R, Imaging the Progression of Intra-tumor Heterogeneity in Prostate and Ovarian Xenografts using Dynamic Contrast-Enhanced CT, Proc. IEEE EMBC, 2005.
Stantz KM, Liu B, Cao M, Reinecke D, Miller K, Kruger R, "Photoacoustic spectroscopic imaging of intra-tumor heterogeneity and molecular identification", Proc. SPIE BIOS 6086:36-47, 2006.
Stantz KM, Cao M, Liang Y, Miller KD, "Evaluating the Therapeutic Response of PS-341 in Xenograft SKOV3x Ovarian Mouse Model by Dynamic Contrast-Enhanced CT", Molecular Imaging and Biology 8(2):73-74, 2006.
Cao M, Liang Y, Miller KD, Stantz KM, "Quantification of Intra-Tumor Physiological Heterogeneity and Therapeutic Response in Xenograft MCF-7 Breast Cancer Model by Dynamic Contrast Enhanced Computed Tomography", Molecular Imaging and Biology 8(2):71, 2006.
Stantz KM, Liu B, Kruger RA, "Using Monte Carlo simulations to understand the influence of photon propagation on photoacoustic spectroscopic imaging", Proc. SPIE BIOS 6437:, 2007
Cao M, Liang Y, Miller K, Stantz KM. Developing DCE-CT to Quantify Intra-Tumor Heterogeneity in Breast Tumors with Differing Angiogenic Phenotypes. IEEE Trans. Med. Imaging 28(6):861-871, 2009.
Stantz KM, Cao N, Liu B, Cao M, Chin-Sinex H, Mendonca M, Li JJ. Effects of Radiation on tumor hemodynamics and NF-kappaB in breast tumors. Proc SPIE BIOS 7564: 2010.
Cheong YJ, Stantz KM. Photon propagation correction in 3D photoacoustic image reconstruction using Monte Carlo Simulation Proc SPIE BIOS 7564: 2010
Stantz KM, Cao M, Liang Y, Miller KD. Monitoring the Longitudinal Intra-Tumor Physiology Impulse Response to VEGFR2 Blockade in Breast Tumors Using DCE-CT. Molecular Imaging and Biology, 2010
Click here for a full CV for Keith M. Stantz. (an Adobe Acrobat file)
This record was last updated on Jun 6, 2013 at 11:41 AM