print-only header

School of Health Sciences Personnel - Keith M. Stantz

Keith M. Stantz, Ph.D.
Associate Professor of Health Sciences
Assistant Professor of Radiology, Indiana University School of Medicine
Phone: 765-496-1874
Fax: 765-496-1377

Full directory listing
Picture of Keith M. Stantz


Valparaiso University,            Valparaiso, IN           B.S       Physics and EECE
Michigan State University,      East Lansing, MI      M.S       Physics
Indiana University,                 Bloomington, IN      Ph.D      Physics
(Thesis: "Search for the lepton-family-number nonconserving decay μ->e+γ", Los Alamos National Laboratories, NM)

Research: Molecular and Physiological Imaging of Hypoxia and Cancer

Dr. Keith Stantz's research interests include: (1) developing photoacoustic computed tomographic (PCT) scanner and analytic methods for in vivo quantification of endogenous (hemoglobin) and exogenous (photoacoustic contrast agents) molecules, (2) developing a new PCT-S scanner for dynamic constrast-enhanced techniques (DCE-CT) for in vivo quantification of vascular physiology in mouse models of cancer, (3) discovering patterns of intra-tumor hemodynamics and oxygenation of cancer to different cancer angiogenic phenotypes, and (4) discovery of biological models linking anti-angiogenic therapeutic-driven hypoxia to cancer stem cells and metastasis.


Physiological Imaging using Dynamic Contrast-Enhance Imaging (DCE-CT)

  • Quantify intra-tumor physiology (perfusion, PS, fp, fis)
  • Influence of tumor angiogenic phenotype in cancer progression
  • Monitor longitudinal intra-tumor hemodynamic response to anti-angiogenic therapy

Molecular Imaging using Photoacoustic CT-spectroscopy

  • Quantify intra-tumor hemoglobin concentrations and oxygen saturation levels (SaO2)
  • Quantify follicle stimulating hormone receptor (FSHR) expression and neuropilin receptor (NRP-1) in ovarian and breast tumors.

Modeling and Tumor Biology

  • Mathematical models of intra-tumor hypoxia: models which fuse in vivo measurements of hemodynamic variables in order to measure tumor oxygenation and hypoxia.
  • Explore properties of tumor hypoxia and influence on cancer stem cells prevalence
  • Hypoxia Models in Radioresistent Tumors and their effects of Anti-angiogenic therapy on their Radiobiology and chemosensitivity

Service and Engagement

See CV


  • HSCI 570 Diagnostic Medical Imaging (3 credit)
  • HSCI 526 Principles of Health Physics and Dosimetry (3 credit)
    Guest Lecturer
  • HSCI 101 Introduction to Health Sciences
  • HSCI 202 Essentials of Environmental, Occupational, and Radiological Health Sciences
  • HSCI 540 Radiation Biology
  • HSCI 698 Seminars in Health Sciences

Honors and Credentials

See CV


See CV

Administration and Committee Work

See CV

Representative Publications

Stantz KM, Liang Y, Hutchins, Gary; "Kinematic Modeling and Its Implication in Longitudinal Chemotherapy Study of Tumor Physiology: Ovarian Xenograft Mouse Model and Contrast-Enhanced Dynamic CT," Proc. SPIE Medical Imaging 5369:769-779, 2004.
Stantz KM, Liang Y, Li X, Kao C, Steinmetz R, Imaging the Progression of Intra-tumor Heterogeneity in Prostate and Ovarian Xenografts using Dynamic Contrast-Enhanced CT, Proc. IEEE EMBC, 2005.
Stantz KM, Liu B, Cao M, Reinecke D, Miller K, Kruger R, "Photoacoustic spectroscopic imaging of intra-tumor heterogeneity and molecular identification", Proc. SPIE BIOS 6086:36-47, 2006.
Stantz KM, Cao M, Liang Y, Miller KD, "Evaluating the Therapeutic Response of PS-341 in Xenograft SKOV3x Ovarian Mouse Model by Dynamic Contrast-Enhanced CT", Molecular Imaging and Biology 8(2):73-74, 2006.
Cao M, Liang Y, Miller KD, Stantz KM, "Quantification of Intra-Tumor Physiological Heterogeneity and Therapeutic Response in Xenograft MCF-7 Breast Cancer Model by Dynamic Contrast Enhanced Computed Tomography", Molecular Imaging and Biology 8(2):71, 2006.
Stantz KM, Liu B, Kruger RA, "Using Monte Carlo simulations to understand the influence of photon propagation on photoacoustic spectroscopic imaging", Proc. SPIE BIOS 6437:, 2007
Cao M, Liang Y, Miller K, Stantz KM. Developing DCE-CT to Quantify Intra-Tumor Heterogeneity in Breast Tumors with Differing Angiogenic Phenotypes. IEEE Trans. Med. Imaging 28(6):861-871, 2009.
Stantz KM, Cao N, Liu B, Cao M, Chin-Sinex H, Mendonca M, Li JJ. Effects of Radiation on tumor hemodynamics and NF-kappaB in breast tumors. Proc SPIE BIOS 7564: 2010.
Cheong YJ, Stantz KM. Photon propagation correction in 3D photoacoustic image reconstruction using Monte Carlo Simulation Proc SPIE BIOS 7564: 2010
Stantz KM, Cao M, Liang Y, Miller KD. Monitoring the Longitudinal Intra-Tumor Physiology Impulse Response to VEGFR2 Blockade in Breast Tumors Using DCE-CT. Molecular Imaging and Biology, 2010

Curriculum Vitae

Click here for a full CV for Keith M. Stantz. (an Adobe Acrobat file)

This record was last updated on Jun 6, 2013 at 11:41 AM
E-mail Webmaster
Maintained by: HHS
This page was last modified at 10:49 AM on June 17, 2010
Purdue University, School of Health Sciences
550 Stadium Mall Drive, West Lafayette, IN 47907-2051,  Phone: (765) 494-1419, FAX: (765) 496-1377
© 2003-2015 Purdue University | An equal access/equal opportunity university | Copyright Complaints
If you have trouble accessing this page because of a disability, please contact us at